PPAR coactivator 1 ERR ligand 1 is an ERR protein ligand, whose expression induces a high-energy expenditure and antagonizes obesity
نویسندگان
چکیده
Departments of *Molecular Medical Science and §Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka 565-0874, Japan; †Graduate School of Biostudies, Kyoto University, Kyoto 606-8501, Japan; ‡Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, ¶Department of Molecular Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo, Tokyo 153-8904, Japan; Research Project for Obesity and Lipid Metabolism Regulation, Biooriented Research Advancement Institution, Tokyo 105-0001, Japan; **Laboratory of Nutrition Chemistry, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan; ††Department of Environmental Health, Nara Women’s University, Nara 630-8506, Japan; and ‡‡Division of Clinical Nutrition, National Institute of Health and Nutrition, Tokyo 162-8636, Japan
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Peroxisome Proliferator-activated Receptor Coactivator-1 (PGC-1 ) Coactivates the Cardiac-enriched Nuclear Receptors Estrogen-related Receptor- and - IDENTIFICATION OF NOVEL LEUCINE-RICH INTERACTION MOTIF
The transcriptional coactivator PPAR coactivator-1 (PGC-1 ) has been characterized as a broad regulator of cellular energy metabolism. Although PGC-1 functions through many transcription factors, the PGC-1 partners identified to date are unlikely to account for all of its biologic actions. The orphan nuclear receptor estrogen-related receptor (ERR ) was identified in a yeast two-hybrid screen o...
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Estrogen-related receptor (ERR ) is one of the first orphan nuclear receptors to be identified, yet its physiological functions are still unclear. We show here that ERR is an effector of the transcriptional coactivator PGC-1 [peroxisome proliferator-activated receptor (PPAR ) coactivator 1 ], and that it regulates the expression of genes involved in oxidative phosphorylation and mitochondrial b...
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The estrogen receptor-related receptor gamma (ERR gamma/ERR3/NR3B3) is the newest member of the ERR subfamily that also includes ERR alpha and ERR beta. All three isoforms share a high degree of amino acid identity especially in the DNA binding domain. ERR gamma is a constitutively active transcriptional activator that regulates reporter elements driven by steroidogenic factor 1 response elemen...
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The human estrogen-related receptor 1 (ERR 1) is a member of an orphan receptor family closely related to the estrogen receptor. It has been demonstrated that estrogen modulates endothelial nitric oxide synthase (eNOS) expression through the estrogen receptor in endothelial cells. However, little is known about the relationship between ERR 1 and eNOS. In this study, we show that ERR 1 activates...
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